LOVASTATIN-INDUCED MITOCHONDRIAL OXIDATIVE STRESS LEADS TO THE RELEASE OF MTDNA TO PROMOTE APOPTOSIS BY ACTIVATING CGAS-STING PATHWAY IN HUMAN COLORECTAL CANCER CELLS

Statins are 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors widely used in the treatment of hyperlipidemia.The inhibition of HMG-CoA reductase in the mevalonate pathway leads to the suppression of cell proliferation and induction of apoptosis.The cyclic GMP-AMP synthase (cGAS) stimulator of the interferon genes (STING) signalin

Numerous host factors function as intrinsic antiviral effectors to attenuate viral replication.MARCH8 is an E3 ubiquitin ligase that has been identified as a host restriction factor that inhibits the replication of various viruses.This study elucidated the mechanism by which MARCH8 restricts respiratory syncytial virus (RSV) replication through sel

Abstract Background Psychosocial support is a crucial component of adequate rare disease care, but to date psychosocial support needs of this patient population are insufficiently met.Within Q.RARE.LI, we strive to evaluate the effectiveness of a structured, transdiagnostic, and location-independent psychosocial support intervention in routine care

A Garden Flag newly developed immunosuppressant, FTY720, has a unique mechanism that is quite different from those of conventional immunosuppressants, and is presumed to be mediated through decreases in the number of peripheral lymphocytes, especially helper T cells.This study was performed to ascertain whether this innovative drug could prolong is